Improvement of skin sensory of cosmetic emulsions containing particulate micronized insoluble organic UV filters agents insoluble therein and / or insoluble micronized inorganic UV filters (01-Sep-2009)
Sensory enhancers improve the skin sensory / end skin feeling of cosmetic or pharmaceutical emulsions containing particulate micronized insoluble organic UV filter agents insoluble therein and / or particulate insoluble inorganic UV filters.
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Improvement of skin sensory of cosmetic emulsions containing particulate micronized insoluble organic UV filters agents insoluble therein and / or insoluble micronized inorganic UV filters
Introduction
The present study relates to the improvement of the skin sensory / end skin feeling of cosmetic or pharmaceuticals emulsions containing particulate micronized insoluble organic UV filters agents insoluble therein and / or insoluble micronized inorganic UV filters in particular zinc oxide and titanium dioxide, which may impact the final touch on skin.
The formulations may exist in a wide variety of preparation forms, for example, creams (more or less viscous) such as Oil/Water (O/W), Water/Oil (W/O), O/W/O, W/O/W, PIT emulsions or micro- emulsions, gels, lotions, milks, sprays, alcoholic or aqueous/alcoholic lotions, milks, wax/fat compositions, stick preparations, powders, tablets, foams, ointments, etc…
Particulate UV filters concerned
The particulate UV absorbers related in the present work are
o the particulate insoluble micronized organic UV filter agents insoluble therein, particle
size 50-200 nm, aqueous dispersion comprising 50% UV absorber active ingredient,
o and / or particulate insoluble inorganic UV filters, particle size 10-200 nm comprising
coated or non coated active ingredients,
The particulate micronized organic UV filter agents insoluble therein are present in the final cosmetic formulation in an amount from about 0,1% to about 10% active ingredients by weight, most preferably from 2% to about 7,5% active ingredient by weight.
The inorganic UV filters are present in the final cosmetic formulation in an amount from about 0,1% to about 10% active ingredients by weight, most preferably from 0,5% to about 4 active ingredient by weight.
The micronized insoluble UV absorber used in the present study may be selected from the compounds of formula
(1)
A1
A1
A1 N
N
N
, wherein
A is a radical of formula (1a) *
R9
R10
R1
R5
*
; or (1b)
R1
;
R3
R2 R3
(CHx)y
R4
R2
R1 and R5 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R2, R3 and R4 independently from each other are hydrogen; or a radical of formula
(1c)
*
R8 , wherein at least one of the radicals R2, R3 and R4 are a radical of formula
(1c);
R6, R7, R8, R9 and R10 independently from each other are hydrogen; hydroxy; halogen; C1-C18alkyl; C1-
C18alkoxy; C6-C12aryl; biphenylyl; C6-C12aryloxy; C1-C18alkylthio; carboxy; -COOM; C1-C18- alkylcarboxyl; aminocarbonyl; or mono- or di-C1-C18alkylamino; C1-C10acylamino; -COOH; M is an alkali metal ion;
x is 1 or 2; and
y is a number from 2 to 10.
R6
R7
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More preferably the insoluble UV absorber is selected from the compounds of formula
(2)
R7 R8
R6
, wherein
R1
R1 R5
R1
N
N
N
R6
R7 R6
R7
R8
R5
R5
R8
R1, R5, R6, R7 und R8 are defined as in formula (1), and preferably R1and...
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