Epididymal injection of calcium chloride dihydrate solution (preferably in alcohol) for nonsurgical sterilization in males

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IP.com Disclosure Number: IPCOM000223843D
Publication Date: 30-Nov-2012
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Elaine Lissner - Author
Elaine Lissner, Director, Parsemus Foundation, author and originator. This idea originated by seeing a connection between the work of two research teams Parsemus Foundation has supported (Jana K et al, calcium chloride testicular injection, and Leoci R et al, chlorhexidine epididymal injection). We encourage researchers, foundations, and the public sector to pursue the idea with the goal of developing a low-cost, nonsurgical alternative to vasectomy.

Abstract

Calcium chloride dihydrate in alcohol, lidocaine, or saline solution has been extensively studied for nonsurgical neuter for male animals. However, when injected into testicular tissue as in those studies, a testosterone reduction results, which would not be appropriate in human males. We propose epididymal rather than testicular tissue injection of calcium chloride dihydrate solution, to avoid affecting testosterone production, as a nonsurgical, non-libido-reducing sterilant in humans. It may also be of use to owners/guardians/managers of companion, zoo, or farm animals who wish to sterilize their animals without changing hormone-linked behavior or health, in addition to providing men with a simple, nonsurgical alternative to vasectomy.

Copyright

Copyright Parsemus Foundation, November 30, 2012

Related Documents

URL http://www.docstoc.com/docs/84562692/Single-Testicular-Injection-of-Chlorhexidine-Solution-as-Chemical Single Testicular Injection of Chlorhexidine Solution as Chemical Sterilant in Dogs. G Aiudi, F Silvestre, R Leoci and GM Lacalandra. Also available directly from the Alliance for Contraception in Cats & Dogs, www.acc-d.org/4thSymposiumProceedings . One example of intraepididymal injection in animals. [+3] [-3]
URL www.esdar.org/services/files/ESDAR%20Poster_Kurzfassung.pdf Poster 155: Efficacy of Intratesticular vs Intraepididymal Injection of Chlorhexidine Solution as Chemical Sterilant in Dogs. R Leoci, G Aiudi, F Silvestre, A Forte, G Lacalandra. Dept. of Animal Production, University of Bari Aldo Moro, Faculty of Veterinary Medicine, Valenzano (Ba), Italy. Another publication about chlorhexidine injection in animals, comparing epididymal to testicular injection, from the Aiudi-Leoci team.
URL http://www.ncbi.nlm.nih.gov/pubmed/670096 Blockage of sperm transport using intraepididymal calcium chloride injections in rams. Bowman TA, Senger PL, Koger LM, Gaskins CT, Hillers JK. Free full text available. An early publication demonstrating the use of calcium chloride dihydrate solution epididymal injection for sterilization in male animals.
URL http://www.ncbi.nlm.nih.gov/pubmed/21774835 Clinical evaluation of non-surgical sterilization of male cats with single intra-testicular injection of calcium chloride. Jana K, Samanta PK. A recent example of the long string of publications from the Jana/Samanta team demonstrating use of TESTICULAR injection of calcium chloride dihydrate solution for sterilization and neuter in male animals. The testosterone reduction stemming from testicular rather than epididymal injection is generally desirable when castrating animals but is not desirable as a non-hormone-altering vasectomy alternative for human family planning.

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English (United States)

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United States

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Calcium chloride dihydrate in alcohol, lidocaine, or saline solution has been extensively studied for nonsurgical neuter for male animals (see Koger LM et al. 1976, 1977, and 1978; Samanta PK and Jana K et al, 1998 to 2011; and Leoci R, forthcoming 2013). However, when injected into testicular tissue as in those studies, a testosterone reduction results that would not be appropriate in human males. We propose epididymal rather than testicular tissue injection of calcium chloride dihydrate solution, to avoid affecting testosterone production, as a nonsurgical, non-libido-reducing sterilant in humans. It may also be of use to owners/guardians/managers of companion, zoo, or farm animals who wish to sterilize their animals without changing hormone-linked behavior or health.

Epididymal injection of calcium chloride dihydrate in saline or alcohol was studied in animals, together with testicular tissue injection, in pilot studies in the 1970’s (see Koger LM, Bovine Practitioner 1977, and Bowman TA et al., Journal of Animal Science Vol. 46 No. 4, 1978). Other chemicals have also been used in animals to sterilize by intra-epididymal injection – for example, Chlorhexidine, in “Efficacy of intratesticular vs intraepididymal injection of Chlorhexidine solution as chemical sterilant in dogs”, R Leoci, G Aiudi, F Silvestre, A Forte, G Lacalandra, Department of Animal Production - University of Bari Aldo Moro, Faculty of Veterinary Medicine, Valenzano (Ba), Italy, presented as poster #155 at The 15th Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR), Antalya, Turkey, 15–17 September 2011.

Though vasectomy is fairly prevalent in industrialized countries, surgical facility challenges limit its use in lower-income countries, and fear of surgery limits its use to generally a maximum of 10-20% of men eve...

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